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Educational Materials

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10 Warning Signs

The Jeffrey Modell Foundation has created the 10 Warning Signs of PI to continue its mission to assure earliest possible diagnosis.

http://downloads.info4pi.org/images/10-Warning-Signs---Generic-Text-resize-900x1145-57ed6acb69314-original     http://downloads.info4pi.org/images/10-Warning-Signs---Adults-resize-900x1145-57ed6abc9e5ef-original     http://downloads.info4pi.org/images/10-Warning-Signs---Illustrated-resize-900x1146-57ed6adbefa7f-original     http://downloads.info4pi.org/images/10-Warning-Signs---Illustrated-Spanish-resize-900x1170-57ed6af73f5d2-original     http://downloads.info4pi.org/images/10-Warning-Signs-English_8-2014-resize-900x1165-53f4c66b96cd8-original

If you or someone you know is affected by two or more of the following Warning Signs, speak to a physician about the possible presence of an underlying Primary Immunodeficiency.

The 4 Stages of Testing Poster

To assist physicians in making a PI diagnosis.

http://downloads.info4pi.org/images/Physician-Algorithm-resize-900x1145-57ed6aacabeaf-original http://downloads.info4pi.org/images/Spanish---4-stages-of-testing-resize-900x1046-57ed737ce040f-original

10 Warning Signs

The Jeffrey Modell Foundation has created the 10 Warning Signs of PI to continue its mission to assure earliest possible diagnosis.

Educational Books

In addition to the 10 Warning Signs Posters we have produced the following educational materials to inform the public about Primary Immunodeficiency.

  • Immune System Posters

    An educational illustration of how our immune system works.

    http://downloads.info4pi.org/images/immune-system---english-child-resize-297x418-55e8626f8f443-original     http://downloads.info4pi.org/images/Immune-System---English-adult-resize-297x417-55e86269b97fc-original     http://downloads.info4pi.org/images/Immune-System---Dutch-child-resize-274x412-55e862640982b-original     http://downloads.info4pi.org/images/Immune-System---Dutch-adult-resize-271x411-55e8625e4ed89-original

    http://downloads.info4pi.org/images/Immune-System---Spanish-resize-297x424-54db91594bd83-original     http://downloads.info4pi.org/images/Immune-System---Polish-resize-409x578-54dbc681991f0-original     http://downloads.info4pi.org/images/Immune-System---Slovene-resize-373x583-54dbc77be4cf2-original     http://downloads.info4pi.org/images/Immune-System---Serbian-resize-383x582-54dbc7e8917b1-original

    http://downloads.info4pi.org/images/Immune-System---German-resize-323x529-54dbbe3469ab4-original     http://downloads.info4pi.org/images/Immune-System---Kazakh-resize-338x519-54dbbe3ad8571-original     http://downloads.info4pi.org/images/Immune-System---Russian-resize-356x518-54dbbe40a0c10-original     http://downloads.info4pi.org/images/Immune-System---Arabic-resize-394x569-5506fb564eba6-original

    http://downloads.info4pi.org/images/immune-system---romanian-resize-402x564-555cb84d934e7-original

  • Informational Brochures

    A pocket-sized guide to PI.

    http://downloads.info4pi.org/images/JMF-Accordion-Brochure-2018---front-back-resize-900x659-5bd9d636da186-original

    http://downloads.info4pi.org/images/Fireman-resize-293x216-5bd9d97aa0dab-original   http://downloads.info4pi.org/images/Rockstar-Spanish-resize-291x216-5bd9d980cc9ea-original

    A detailed and informative guide to PI.

    http://downloads.info4pi.org/images/JMF_SlimJim_2013_Spread-resize-245x195-537a902107b11-original        

    As well as in collaboration with our pharmaceutical partners!

    http://downloads.info4pi.org/images/Everyone-Gets-Sick---But-How-Often-is-Too-Often_Page_1-resize-900x1165-53f50752e7a07-original   

    http://downloads.info4pi.org/images/PI-Know-the-WS---English-resize-408x324-54dbcbf183ebb-original         http://downloads.info4pi.org/images/PI-Know-the-WS---Bosnian-resize-419x323-54dbcc013843b-original

    http://downloads.info4pi.org/images/10-WS-Bosnian-Pamphlet-resize-864x430-54dbcd66bef9d-original

  • Why Immunology?

    The Importance of the Immune System!

    http://downloads.info4pi.org/images/Why-Immunology---5-slides-resize-899x426-568560607011b-original

  • Funny Immunology To Save Lives!

    English
    http://downloads.info4pi.org/images/COVER-BOOK-1-resize-681x968-57b35a0b4a79f-original   http://downloads.info4pi.org/images/COVER-BOOK-2-resize-900x1278-57b35a1b6d9e5-original   http://downloads.info4pi.org/images/COVER-BOOK-3-resize-900x1278-57b35a2d201ce-original   http://downloads.info4pi.org/images/COVER-BOOK-4-resize-900x1269-57b35a46339fc-original   http://downloads.info4pi.org/images/COVER-BOOK-5-resize-900x1276-57b35a53318b7-original
    http://downloads.info4pi.org/images/COVER-BOOK-6-resize-900x1273-57b35a69687ca-original   http://downloads.info4pi.org/images/COVER-BOOK-7-resize-900x1273-57b35a8423724-original   http://downloads.info4pi.org/images/COVER-BOOK-8-resize-900x1273-57b35a97021fe-original   http://downloads.info4pi.org/images/COVER-BOOK-9_ENG-resize-794x1123-57b35aa4b379f-original   http://downloads.info4pi.org/images/Volume-10-Cover-resize-900x1273-57b35abd3ff2b-original

    Spanish
    http://downloads.info4pi.org/images/Tapa-resize-681x957-57b482c9312ac-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-2-resize-873x1240-57b482d6c87de-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-3-resize-874x1240-57b482e0b789f-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-4-resize-874x1240-57b482eee397e-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-5-resize-874x1240-57b482fa3d53f-original
    http://downloads.info4pi.org/images/CUBIERTA-LIBRO-6-resize-900x1280-57b4830c2d9eb-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-7-resize-900x1278-57b4832287cc6-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-8-resize-900x1274-57b48335b2cc5-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-9-resize-900x1273-57b48344d2ec5-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-10-resize-900x1280-57b48357350a4-original

    Portuguese
    http://downloads.info4pi.org/images/Livro-1---OS-LEUCOCITOS_Page_01-resize-900x1273-57b36b5689690-original   http://downloads.info4pi.org/images/Livro-2---OS-LEUCaCITOS-CONTRA-A-CANDIDA_Page_01-resize-900x1273-57b36b65e8bf1-original   http://downloads.info4pi.org/images/Livro-3---OS-LEUCaCITOS-CONTRA-OS-MYCOS_Page_01-resize-900x1273-57b36b70aa504-original   http://downloads.info4pi.org/images/Livro-4---OS-LEUCaCITOS-CONTRA-O-ASCARON_Page_01-resize-900x1273-57b36b7c1d800-original   http://downloads.info4pi.org/images/Livro-5---OS-LEUCaCITOS-CONTRA-OS-PNEUMOCOCOS_Page_01-resize-900x1273-57b36b87d4579-original
    http://downloads.info4pi.org/images/Livro-6---OS-LEUCaCITOS-CONTRA-O-C-NCER_Page_01-resize-900x1273-57b36b9772110-original   http://downloads.info4pi.org/images/Livro-7---LINFaCITOS-T-REGULATaRIOS_Page_01-resize-900x1273-57b36ba32f318-original   http://downloads.info4pi.org/images/Livro-8--QUANDO-OS-LEUCaCITOS-FICAM-DOENTES_Page_01-resize-900x1273-57b36bae95f7f-original   http://downloads.info4pi.org/images/Livro-9--QUANDO-OS-LEUCaCITOS-FICAM-LOUCOS_Page_01-resize-900x1273-57b36bb9da116-original   http://downloads.info4pi.org/images/Livro-10---OS-LEUCaCITOS-E-O-TRANSPLANTE_Page_01-resize-900x1273-57b36bc7877dd-original

  • The Fantastic Interleukins

    English

    http://downloads.info4pi.org/images/Chapters-1_12-Cover-resize-720x960-5b201dc07c7d4-original  http://downloads.info4pi.org/images/Chapters-13_25-Cover-resize-720x960-5b201dca69cca-original  http://downloads.info4pi.org/images/Chapters-26_38-Cover-resize-720x960-5b201dd45dafc-original

    Spanish

    http://downloads.info4pi.org/images/Capítulos-1---12-Cover-resize-720x960-5b201de8a9fde-original  http://downloads.info4pi.org/images/Capítulos-13---25-Cover-resize-720x960-5b201e003537d-original  http://downloads.info4pi.org/images/Capítulos-26---38-Cover-resize-720x960-5b201e10f2bc3-original

Physician Education Materials

http://downloads.info4pi.org/images/Doctor-resize-92x250-533edc767dffe-original

The clinical presentation of PI can be diverse. However, there are clinical findings at the level of different organs and systems requiring PI suspicion; these findings must be quickly recognized by specialty care physicians:

La presentación clínica de las IDP puede ser muy variada. Sin embargo, existen hallazgos clínicos a nivel de diferentes órganos y sistemas que obligan a sospechar IDP; estos hallazgos deben ser rápidamente reconocidos por los médicos especialistas:

  • Interesting Scientific Research
    • The FILL (Following infants with low lymphocytes) study developed as an offshoot and direct result of newborn screening for SCID and T cell lymphopenia (NBS SCID) in the United States.  This study intends to enroll infants who are initially identified during newborn screening (abnormal TREC result on SCID screening) and confirmed by a physician to have lymphopenia.  The study will collect data on 200 infants who are enrolled by April 1, 2018.  The FILL database was created and is maintained by the USIDNET, through a pilot grant provided by the Jeffrey Modell Foundation to the Clinical Immunology Society (CIS).   Patient data can be entered into the FILL Database either by enrollment through an USIDNET center, or through direct physician referral to USIDNET.  All patients enrolled in the study have to be consented through an IRB protocol.

      We strongly urge you to enroll your patients with T cell lymphopenia identified by SCID newborn screening in the FILL study so that there is evidence-based data to better understand, follow and manage infants with lymphopenia.

      http://downloads.info4pi.org/images/FILL_postcard-HR-Print-resize-899x582-592ddb9fcad57-original

    • Clinical Trial Opportunity for Patients with Chronic Mucocutaneous Candidiasis
      Chronic Mucocutaneous Candidiasis often results from an underlying immune deficiency that leads to abnormalities in a person’s control of fungal infections such as candida.  Investigators at NIAID are seeking people with chronic mucocutaneous candidiasis (oropharyngeal, esophageal or vulvovaginal candidiasis) that are refractory or intolerant to standard non-intravenous therapies to participate in a clinical research trial.  For additional information please contact Dr. Alexandra Freeman (freemaal@mail.nih.gov) or see https://clinicaltrials.gov/ct2/show/NCT02629419.

    • Monozygotic twins discordant for CVID reveal impaired DNA demethylation during naïve-to-memory B-cell transition

    • 'JEDI' technology awakens new understanding of how immune system works
  • Educational Materials for Physicians and Their Patients

    Saving Children with Agammaglobulinemia (Salvando A Los Niños Con Agammaglobulinemia)
    www.savingagammaglobulinemiapatients.org

  • Clinical Trials, Physician Research Opportunities
    • X4 Pharmaceuticals planning to start a Phase 3 clinical study: “A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial of mavorixafor (X4P-001) in Patients with WHIM Syndrome with Open-Label Extension”

    WHIM (Warts, Hypogammaglobulinemia, Infections and Myelokathexis) is a rare autosomal dominant primary immunodeficiency disease caused by gain-of-function mutations in the chemokine receptor CXCR4.  CXCR4 mutations induce increased leukocyte homing and retention in the bone marrow resulting in severe chronic neutropenia and lymphopenia.  

    X4 Pharmaceuticals is planning to sponsor a 52-week global Phase 3 study to evaluate the safety and efficacy of mavorixafor, a once-daily oral CXCR4 antagonist, in genetically confirmed WHIM patients who are aged 12 years or older.  Mavorixafor is a first-in-class, oral, small molecule antagonist of the CXCR4 chemokine receptor that has demonstrated a favorable safety profile and dose-dependent increases in ANC and ALC in a Phase 2 study. Trial subjects will participate in a one-year trial with an opportunity to continue in the subsequent open label extension.  Travel support to study sites will be provided. 

    To support confirming the diagnosis of WHIM, X4 Pharmaceuticals will offer genetic testing at no charge to patients meeting eligibility criteria suggestive for the disease.  For information and support for genetic confirmation of your patients with suspected WHIM, please contact patientinfo@x4pharma.com.

    To learn more about X4 Pharmaceuticals, visit their website, at x4pharma.com

    • The FILL (Following infants with low lymphocytes)

    This study developed as an offshoot and direct result of newborn screening for SCID and T cell lymphopenia (NBS SCID) in the United States.  This study intends to enroll infants who are initially identified during newborn screening (abnormal TREC result on SCID screening) and confirmed by a physician to have lymphopenia.  The study will collect data on 200 infants who are enrolled by April 1, 2018. The FILL database was created and is maintained by the USIDNET, through a pilot grant provided by the Jeffrey Modell Foundation to the Clinical Immunology Society (CIS).   Patient data can be entered into the FILL Database either by enrollment through an USIDNET center, or through direct physician referral to USIDNET.  All patients enrolled in the study have to be consented through an IRB protocol.

    We strongly urge you to enroll your patients with T cell lymphopenia identified by SCID newborn screening in the FILL study so that there is evidence-based data to better understand, follow and manage infants with lymphopenia.

    http://downloads.info4pi.org/images/FILL_postcard-HR-Print-resize-899x582-592ddb9fcad57-original

    • Clinical Trial Opportunity for Patients with Chronic Mucocutaneous Candidiasis

    Chronic Mucocutaneous Candidiasis often results from an underlying immune deficiency that leads to abnormalities in a person’s control of fungal infections such as candida.  Investigators at NIAID are seeking people with chronic mucocutaneous candidiasis (oropharyngeal, esophageal or vulvovaginal candidiasis) that are refractory or intolerant to standard non-intravenous therapies to participate in a clinical research trial.  For additional information please contact Dr. Alexandra Freeman (freemaal@mail.nih.gov) or see https://clinicaltrials.gov/ct2/show/NCT02629419.

  • Funny Immunology To Save Lives!

    English
    http://downloads.info4pi.org/images/COVER-BOOK-1-resize-681x968-57b35a0b4a79f-original   http://downloads.info4pi.org/images/COVER-BOOK-2-resize-900x1278-57b35a1b6d9e5-original   http://downloads.info4pi.org/images/COVER-BOOK-3-resize-900x1278-57b35a2d201ce-original   http://downloads.info4pi.org/images/COVER-BOOK-4-resize-900x1269-57b35a46339fc-original   http://downloads.info4pi.org/images/COVER-BOOK-5-resize-900x1276-57b35a53318b7-original
    http://downloads.info4pi.org/images/COVER-BOOK-6-resize-900x1273-57b35a69687ca-original   http://downloads.info4pi.org/images/COVER-BOOK-7-resize-900x1273-57b35a8423724-original   http://downloads.info4pi.org/images/COVER-BOOK-8-resize-900x1273-57b35a97021fe-original   http://downloads.info4pi.org/images/COVER-BOOK-9_ENG-resize-794x1123-57b35aa4b379f-original   http://downloads.info4pi.org/images/Volume-10-Cover-resize-900x1273-57b35abd3ff2b-original

    Spanish
    http://downloads.info4pi.org/images/Tapa-resize-681x957-57b482c9312ac-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-2-resize-873x1240-57b482d6c87de-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-3-resize-874x1240-57b482e0b789f-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-4-resize-874x1240-57b482eee397e-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-5-resize-874x1240-57b482fa3d53f-original
    http://downloads.info4pi.org/images/CUBIERTA-LIBRO-6-resize-900x1280-57b4830c2d9eb-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-7-resize-900x1278-57b4832287cc6-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-8-resize-900x1274-57b48335b2cc5-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-9-resize-900x1273-57b48344d2ec5-original   http://downloads.info4pi.org/images/CUBIERTA-LIBRO-10-resize-900x1280-57b48357350a4-original

    Portuguese
    http://downloads.info4pi.org/images/Livro-1---OS-LEUCOCITOS_Page_01-resize-900x1273-57b36b5689690-original   http://downloads.info4pi.org/images/Livro-2---OS-LEUCaCITOS-CONTRA-A-CANDIDA_Page_01-resize-900x1273-57b36b65e8bf1-original   http://downloads.info4pi.org/images/Livro-3---OS-LEUCaCITOS-CONTRA-OS-MYCOS_Page_01-resize-900x1273-57b36b70aa504-original   http://downloads.info4pi.org/images/Livro-4---OS-LEUCaCITOS-CONTRA-O-ASCARON_Page_01-resize-900x1273-57b36b7c1d800-original   http://downloads.info4pi.org/images/Livro-5---OS-LEUCaCITOS-CONTRA-OS-PNEUMOCOCOS_Page_01-resize-900x1273-57b36b87d4579-original
    http://downloads.info4pi.org/images/Livro-6---OS-LEUCaCITOS-CONTRA-O-C-NCER_Page_01-resize-900x1273-57b36b9772110-original   http://downloads.info4pi.org/images/Livro-7---LINFaCITOS-T-REGULATaRIOS_Page_01-resize-900x1273-57b36ba32f318-original   http://downloads.info4pi.org/images/Livro-8--QUANDO-OS-LEUCaCITOS-FICAM-DOENTES_Page_01-resize-900x1273-57b36bae95f7f-original   http://downloads.info4pi.org/images/Livro-9--QUANDO-OS-LEUCaCITOS-FICAM-LOUCOS_Page_01-resize-900x1273-57b36bb9da116-original   http://downloads.info4pi.org/images/Livro-10---OS-LEUCaCITOS-E-O-TRANSPLANTE_Page_01-resize-900x1273-57b36bc7877dd-original

  • Diagnostic Algorithm for Specialty Care Physicians

    http://downloads.info4pi.org/images/PI-WS-for-Doc---English-resize-375x608-54de117f081eb-original     http://downloads.info4pi.org/images/PI-WS-for-Doc---Spanish-resize-373x608-54de118636b59-original     http://downloads.info4pi.org/images/portuguese-algorithm-resize-510x608-563224cfd7b48-original

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